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Multi- and Single-Reader Sample Size Program 1.0 for Diagnostic Studies

The Multi- and Single-Reader Sample Size Sample Size Program for Diagnostic Studies performs sample size computations for diagnostic reader-performance studies. Such studies are commonly used in radiology, where radiologists evaluate images resulting from an imaging modality (such as mammography for breast cancer) with respect to confidence of disease. In the most common study design, each reader reads all cases under each test. It is this initial study design that this first release (1.0) assumes. Other designs will be included in the near future. The program requires parameter estimates that are either conjectured or obtained from pilot data. Pilot data estimates can be obtained from analyses of data sets that use the method proposed by Obuchowski & Rockette and by Dorfman, Berbaum and Metz, and updated by Hillis and colleagues.

Brief Instructions

The program will run under Windows, macOS, and Linux. However, you must have a Java run-time environment (JRE) installed. The process of obtaining the JRE varies with operating system. To install the program, simple download the “Executable” file below. This is an executable jar file. Users may also wish to download the “Instructions” file below which provides a description of obtaining the current JRE for Windows. To run the program, simply double-click the executable jar file. The name of the jar file will be of the form pssYYYYMMDD.jar where YYYYMMDD is the date of the current version of the program (e.g., pss20170828.jar). The user manual is contained within the jar file and may be accessed using the Help menu in the program (it is also available as a separate download below).

Note to macOS and Linux users: The program has only been tested using the JRE provided by Oracle. Use of other JREs is possible but not supported.


 TitleDescriptionModified Date 
Hillis & Schartz (2015) Proc. SPIEDemonstration of multi- and single-reader sample size article8/28/2017Download
InstructionsDownload and installation instructions8/28/2017Download
User ManualUser manual for the power program8/28/2017Download
ExecutableExecutable JAR file8/28/2017Download
Van Dyke sample data setSample data file for use with power program8/28/2017Download

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